Hernando de Cataño was chosen to offer his medical services in Puerto Rico during Francisco Bahamonde de Lugo's tenure as Governor of Puerto Rico (1564–1568). He was one of the first physicians who arrived in Puerto Rico during its colonization and, upon accepting his position, received as payment a piece of land across the San Juan islet. From that time, the region started to be recognized by the name of its original owner. As people started establishing in the area, Cataño was declared as a barrio of Bayamón. However, there wasn't much success in the town's development during these years due to its swamp-like terrain. Still, around 1690, a hermitage was established to allow residents to receive religious services without having to travel to Bayamón.